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EML4-ALK fusion variant

Which EML4-ALK fusion variant does ATCC® CCL-185IG ™ contain?

The EML4-ALK gene fusion that is caused by a chromosomal inversion can produce constitutively active ALK tyrosine kinase protein, which leads to enhanced cell survival and proliferation. There are multiple EML4-ALK fusion variants, and the most prevalent is variant 1 (E13; A20) where the EML4 intron 13 is fused with ALK intron 20.  The EML4-ALK Fusion-A549 Isogenic cells (ATCC® CCL-185IG ™) was created at ATCC using CRISPR/Cas9 gene editing technology and contains the EML4-ALK fusion variant 1 (E13; A20).
Date Created01/18/2016 10:19 AM
Date Updated01/18/2016 10:20 AM

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