Modeling, Screening, Characterizing
Are you in the preliminary stages of toxicity testing?
Modeling, screening, and characterizing candidate therapeutics happens at a rapid pace. Drug development scientists need to be able to screen an astronomical number of these biological and chemical entities to eliminate all but a few strong candidates for further interrogation. ATCC can get you started on the path to success in the preclinical arena with our complete solution of continuous cell lines, growth reagents, and cell viability assays.
- Continuous Cell Lines – Eliminate large numbers of chemical entities by using high- throughput screening. ATCC offers authenticated cell lines from all physiological systems of the body.
- Cell Growth Reagents – We offer uniquely formulated media, sera, and reagents to virtually guarantee successful cell culture.
- Cell Viability Assays – Track the effects of a prospective compound by using an ATCC Cell Proliferation Assay kit. These assays are convenient, easy-to-use, and measure viability and growth.
Hepatic and Renal Cell Lines
The liver and kidney are responsible for detoxifying and excreting exogenous compounds, respectively. Immortalized liver and kidney cell lines are among the most widely used in vitro models for initial toxicity testing due to their high proliferative capacity. Rule out possible toxicities faster by using ATCC authenticated hepatic and renal cell lines.
Skin Cell Lines
Irritation and destruction of the epidermis are red flags to scientists working on topically applied preparations. ATCC offers a wide selection of dermal cell lines, such as keratinocytes, melanocytes, and dermal fibroblasts to study the effect of cosmetics, dyes, and other chemical entities on skin.
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Airway Cell Lines
The mammalian respiratory system is a delicate interface between the atmosphere and the cardiovascular system. To quickly screen the noxious effects of gasses and other exogenous compounds on the airway, ATCC provides a wide variety of continuous cell lines derived from the bronchus, lung, trachea, and larynx.
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Cardiovascular Cell Lines
A large proportion of drugs fail in early clinical phases due to cardiovascular problems. To help researchers screen compounds that may be toxic to the cardiovascular system, ATCC provides a wide variety of endothelial and smooth muscle continuous cell lines derived from the heart, aorta, arteries, veins, and capillaries.
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Neural Cell Lines
A challenge for many toxicologists is that many neural subtypes have low mitotic rates or are difficult to subculture. Neural tissue-derived cell lines provide a proliferating, easy-to-grow solution for identifying potential neurotoxicities in novel chemical entities. To quickly screen for toxic effects on the airway, ATCC provides a wide variety of continuous neural cell lines of multiple species such as neurons and the supporting cells of the central and peripheral nervous system.
Cell Culture Reagents
ATCC high-performance media, sera, and reagents are uniquely formulated according to the cell growth conditions recommended by our cell culture specialists. These are the same reagents used to culture and distribute ATCC cell lines, virtually guaranteeing a successful cell culture.
Cell Culture Reagents
Cell Viability Assays
Measure cell proliferation, cytotoxicity, and apoptosis in a fast, simple, high-throughput assay format. Evaluate a cell population's response to external factors that may result in an increase in cell growth, no effect, or a decrease in growth due to necrosis or apoptosis.
Don’t see the toxicology tool you’re looking for? ATCC has the knowledge, experience, and meticulous methodologies to support your custom needs. Leverage our 95 years experience as a partner in life science discovery. Whether you are looking for the large-scale manufacture of cell lines (master and working cell banks) or a different specification/format than offered in our catalog, ATCC can provide you with customized options to reach your research goals.
Explore ATCC Custom Solutions