Antimicrobial Resistance:

A Broad-spectrum Public Health Crisis

2/13/2020


Abstract

The first modern mainstream antibiotic, penicillin, was introduced for common use in 1942. Reports of penicillin resistance began with Staphylococcus aureus isolated in hospitals- in 1942. In 2019, over 2.8 million cases of antimicrobial-resistant (AMR) infections were reported by the CDC in the United States alone, making it a serious global health threat, and prevalence is steadily rising. Our understanding of the AMR phenomenon is constantly advancing and evolving our knowledge of how resistance mechanisms work, what causes drug resistance, how it spreads, and who is affected. This two-part webinar highlights the growing global threat caused by AMR infections. In part one of this webinar, we will provide an overview of drug resistance mechanisms, their spread, and current knowledge about the global impact of AMR infections.

Key Takeaways:

  • Understanding the true burden of antimicrobial resistant infections: explaining the global prevalence and epidemiology of drug-resistant infections, breaking down morbidity and mortality of the most critical pathogens, and underlining the unsustainable toll that AMR infections take.
  • Explaining how drug resistance works: demonstrating how antibiotics and other antimicrobial compounds work, the molecular mechanisms employed by AMR pathogens to evade these drugs, and how resistance continues to spread.

Presenters

Christine Fedorchuk

Christine Fedorchuk, Ph.D.,
Senior Biologist, ATCC

Dr. Christine Fedorchuk is a Senior Biologist at ATCC Microbiology Research and Development. Dr. Fedorchuk has substantial experience in the fields of microbiology, molecular biology, and immunology. At ATCC, her work includes designing synthetic DNA and RNA molecular standards, studying antimicrobial drug susceptibility in antimicrobial resistant (AMR) bacterial strains, and analyzing AMR-associated genetic sequences. Prior to joining ATCC, her work focused on host-pathogen interactions and the study of virulence gene expression and adherence in foodborne bacterial pathogens. Dr. Fedorchuk earned her doctoral degree from the Pennsylvania State University.