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Isogenic Cell Lines

Clinically relevant cell models are critical for studies of molecular and cellular mechanisms of tumors, as well as for drug screening for cancer. With genome editing tools such as CRISPR/Cas9, ATCC has created isogenic cell lines with mutants of key oncogenes, which are ideal for identifying novel, personalized treatment regimens.

  • Engineered on commonly used tumor cell lines that are highly relevant to diseases and drug targets
  • Thorough molecular validation at genomic, transcript, and protein levels
  • Additional biofunctional characterization with specific inhibitors to demonstrate drug-screening applications

Start your drug screening studies with the new isogenic cell lines!


CRISPR/Cas9 Genome Editing

CRISPR, an advanced genome editing technology, enables precise modifications in the genomes of eukaryotic cells. Learn more about how ATCC creates and validates isogenic cell lines, and explore our new custom genome editing service:

CRISPR-edited Isogenic Cell Lines Video
CRISPR/Cas9 Custom Service

Advanced Isogenic Cell Models

EML4-ALK Fusion – A549 Isogenic Cell Line
NRAS Q61K – A375 Isogenic Cell Line
KRAS G13D – A375 Isogenic Cell Line
MEK Q56P – A375 Isogenic Cell Line
IDH1 R132H – U-87 Isogenic Cell Line
IDH2 R140Q – TF-1 Isogenic Cell Line

By utilizing the CRISPR/Cas9 gene editing, ATCC offers advanced isogenic cell models such as the EML4-ALK fusion lung cancer cell line and BRAF inhibitor-resistant melanoma cell lines. These cell lines are ideal in vitro models for anti-cancer drug screening.

Parental Cell Lines

Tumor Cell Panels
Tumor Cells by Source Tissue
Tumor Cells by Genetic Alteration

A broad range of tumor cell lines and cell panels are offered by ATCC for the study of tumor biology, drug discovery applications, and high-throughput screening.