ATCC offers well-characterized cells that can be used to refine traditional cell-based experiments or construct high-throughput assays, reducing the need for in vivo studies.
Physiologically relevant cell-based assays are critical for the biomedical and toxicity data that cannot be obtained from animal models or humans. ATCC provides the cells needed to explore lung, skin, cardiovascular, gastrointestinal, liver, kidney, and neural toxicity for such applications as high-content screening, 3D culture, spheroid culture, permeability assays, metabolic stability and survival, and more.
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Renal Uptake Screening Tools
OAT1 HEK 293T/17 Cells
ATCC offers OAT1 and OCT2 cells, which stably express soluble transporter proteins that play key roles in the kidney’s clearance of drugs and endogenous compounds. These cell lines are a superior model for nephrotoxicity screening and renal physiology studies.
Browse Kidney Cell Lines
ATCC’s holdings include a vast collection of kidney-derived cell lines, representing the normal and diseased tissue of multiple species. Many of these cells can be used to build reliable models for the study of urolithiasis, renal function, glomerulonephritis, and kidney cancer.
Physiologically Relevant Controls
Primary Kidney Cells
All experiments should include physiologically relevant controls. ATCC provides both primary and hTERT-immortalized renal epithelial cells. We offer cells from the renal proximal convoluted tubule, the renal cortex, and mixed epithelial cells. These cells are well-suited for normal renal physiology studies, toxicological screens, and drug discovery applications.