Toxicology Testing

As toxicologists, we are challenged to identify the adverse effects of a broad range of substances to protect people and the environment. It is critical that the standards and model organisms used in toxicological testing are reliable and authenticated. ATCC has the credible models that you need to perform standardized, reliable, and reproducible toxicology studies.

ATCC provides the cells, media, and reagents needed to explore renal, neural, airway, and skin toxicity for such applications as high-content screening, 3D culture, spheroid culture, permeability assays, metabolic stability and survival studies, transport activity measurement, and more. These toxicological tools can be used to identify responses to environmental insults or to screen pharmaceutical compounds.

Hepatic and Renal Clearance

Testing for absorption, distribution, metabolism, and elimination is crucial to moving your product to market. Get closer results to those observed in vivo and rule out possible toxicities faster by using our entire ADME portfolio, featuring our hTERT-immortalized renal transport protein-expressing kidney cells and upcyte® Hepatocytes. ATCC is here to support your metabolic stability, metabolite identification, and drug-drug interaction assays with our renal and hepatic models.

Hepatic and Renal Clearance Models:
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Astrocytes

Neurotoxicity

Cells of the nervous system are well-specialized and rarely undergo mitosis once differentiated. ATCC offers many cell lines derived from neural tissues and neural progenitor cells that can be easily differentiated into those needed for neurotoxicity studied. Work with differentiating or terminally differentiated neurons, astrocytes, and oligodendrocytes sooner—yield experimental results faster: 

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krt14-filiggrin

Dermal (Skin) Toxicology

ATCC offers a wide selection of cell lines, primary cells, and hTERT-immortalized cells for modeling of the skin. In addition, we supply media and supplements that support cell culture conditions in the presence or absence of serum. These products can be utilized to create 3D skin models or used in basic assays that comply with OECD standards:

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primary bronchial

Airway Toxicity

ATCC offers primary airway epithelial cells, smooth muscle cells (SMCs), and fibroblasts, as well as growth media and media supplements for in vitro models, to boost the scientific relevance of upper respiratory studies. Our materials make it simple to test for tissue variability, cytotoxicity, and more:

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pipettes

Cell Viability Assays

Measure cell proliferation, cytotoxicity, and apoptosis in a fast, simple, high-throughput assay format. Evaluate a cell population's response to external factors that may result in an increase in cell growth, no effect, or a decrease in growth due to necrosis or apoptosis.
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Application Data

Discover toxicological application data

Toxicologists are challenged to identify the adverse effects of a broad range of substances to protect people and the environment. The model organisms used in toxicological testing must be reliable and authenticated. ATCC offers application data for cell models such as hTERT-immortalized renal solute carrier cells, keratinocytes, and melanocytes.

Media and Sera

Classical Media
Animal Sera
Supplements
Buffers and Stains
Dissociation Reagents
Cryopreservation Media and Tools
Specialty Media

ATCC high-performance media, sera, and reagents are uniquely formulated according to the cell growth conditions recommended by the original cell line depositors and ATCC cell culture specialists. These are the same reagents used to culture and distribute ATCC cell lines, virtually guaranteeing a successful cell culture. 

Custom Services

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Need an affordable or unique solution such as assay-ready cells in the format of your choice for toxicity screening for drug, cosmetic, or environmental safety? ATCC can help with customized services and solutions to meet your specific assay development needs.