Reproducibility in Context

Cell Line Authentication Training Reproducibility in Context

2.1 Introduction to Reproducibility

Knowledge Check

What percentage of studies do you think are reproducible in biology?

100%
80%
60%
40%
20%
10%
Never
Pie chart of percentage of guesses

2.2 Rates of Research Reproducibility; 2.3 Len Freedman; 2.4 Glenn Begley

Knowledge Check

What is the approximate irreproducibility rate?

Less Than 10%
Between 10 and 50%
Between 50 and 90%
Greater than 90%

Answer

Between 50 and 90%

2.5 Four Major Contributors to Reproducibility; 2.6 Jon Lorch; 2.7 Veronique Kiermer; 2.8 Focus on Cell Lines

Quiz

Name the four major contributors to the reproducibility problem

Fraud
Misconduct
Biological Reagents
Study Design
Data Analysis & Reporting
Lab protocols
Unpublicized previous retractions
Other

Answers

Biological Reagents, Study Design, Data Analysis & Reporting, and Lab protocols

Reflection Question